Myelofibrosis – What It Is, Causes and Treatments

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Myelofibrosis – What it is, Causes and Treatments  that should not be ignored. Also,  myelofibrosis (MF) is a type of blood cancer. It is characterized by the progressive increase of reticulin fibers in the bone marrow , which eventually occupies the production space of normal blood cells. Fibrosis appears as an alteration of megakaryocytes and mesenchymal cells, which are dysfunctional. The consequence of this is the appearance of anemia and a fall in white blood cells. There may be decreased or increased platelets.

In MF, bone marrow cells  begin to develop and function abnormally, producing giant cells called megakaryocytes. These megakaryocytes rupture, releasing from hundreds to thousands of platelets. A fibrous tissue (scar) then forms in the spinal cord, causing problems with its proper functioning. So check out  Myelofibrosis – What It Is, Causes and Treatments:

What is myelofibrosis?

The Myelofibrosis  belongs to a group of diseases called myeloproliferative neoplasms, also blood cancer calls. People with myelofibrosis  suffer some dysfunction in their bone marrow , which leads to overproduction or underproduction of various blood cells.

Causes of Myelofibrosis?

In Myelofibrosis , a fibrous tissue replaces the precursor cells of normal blood cells, and so it produces anomalous cells in exaggerated quantity. This disorder may be primary or secondary, arising from other conditions (lymphomas, tuberculosis , infections, toxic substances, radiation, etc.). If primary, its cause cannot be determined and may originate from some unknown organism dysfunction.

Myelofibrosis Treatment?

The treatment of primary or secondary myelofibrosis also tends to be quite similar but is still quite limited. The only treatment that can offer a radical cure is stem cell transplantation. Some medications, although palliative, help to improve patients’ quality of life.

How do you develop myelofibrosis?

The disease progresses slowly over an average of ten years, but can become disabling in the medium or long term and can best be controlled when discovered early.

The Myelofibrosis  greatly decreases the lifetime of a person, but the inconvenience caused by it can be minimized when it is done early diagnosis. Patient survival after stem cell transplantation is estimated to be around 30%, but patients’ advanced age makes surgery unfeasible for most patients.

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Possible Complications of Myelofibrosis?

The Myelofibrosis  primary may progress to acute myeloid leukemia in a short time, when not receiving the proper treatment, complication that can easily lead to death.

The available treatments for Myelofibrosis consist of controlling the disease (avoiding worsening of the condition) and alleviating the discomfort caused by the main symptoms. Currently, only stem cell transplantation can cure MF, but is rarely employed as it poses risks to the patient.

Blood transfusion, use of various medications such as thalidomide, androgens and antimetabolites can be employed alone or in combination. Radiotherapy or spleen removal are also measures used, especially when their size is excessively large.

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